Welcome

The George Pantziarka TP53 Trust is the UK’s only charity dedicated to supporting families with Li Fraumeni Syndrome and related conditions. It offers practical support and advice, publishes information for patients and doctors alike and is dedicated to making a difference with research. Where most research is devoted to understanding the disease, the Trust is aiming to move forward with research on how to reduce the massive cancer risks that blight the lives of LFS families. We can make a difference – with your support.

Red Flags!

What to look out for if you have children with LFS and you're concerned that they are unwell

Newly diagnosed?

You've got lots of questions... Visit our FAQs for some of the answers

Do I need a TP53 Test?

Worried that you might have LFS? Not sure how to get tested?

Metformin Clinical Trial

The MILI trial will test the drug metformin to see if it reduces cancer risk

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